Single Family for Sale: 221 W Saint Joseph Street, Perryville, MO 63775

6 beds
4 full, 1 half baths
3,143 sqft
$560,000
$560,000
221 W Saint Joseph Street, Perryville, MO 63775
6 beds
4 full, 1 half baths
3,143 sqft
$560,000
Remove from
Favorites
Add to
Favorites
Add to
Trip Map
Hide Share or
Email
Price:
$560,000

Type Single Family
Style 2 Story
Beds 6
Baths 4 full, 1 half baths
Total Living Area 3,143 sqft
Square Footage 3,143 sqft
Lot Size 0.37 acres
Year Built 1910
Taxes Paid $4,078

City Perryville
County Perry
School District Perry Co. 32
Subdivision Fifth Principal Meridian

MLS 25081439
Status Active
DOM 209 days
Looking for a turn key, fully operational business in the heart of Perryville? The Mediterranean House presents a rare opportunity to own a luxury property designed to host unforgettable stays and events. Currently operating as a successful and versatile venue, this property is well suited for use as an Airbnb, bed and breakfast, or a destination for corporate retreats, wellness or yoga getaways, and private events. The home features six beautifully appointed bedrooms, four full bathrooms, and one half bathroom, offering ample accommodations for guests. A commercial grade kitchen equipped with stainless steel appliances is ready to support culinary experiences, from baking and cooking workshops to catered events. All furniture stays, including antique furnishings, bedroom suites, dining room suites, etc. With its flexible layout and elegant setting, The Mediterranean House is ideal for bridal and baby showers, birthday celebrations, intimate gatherings, or larger hosted events. This is a truly turn key business opportunity, ready for immediate operation, offering the space, functionality, and charm to bring a wide range of visions to life.

Room Features

Basement Description Full

Lot & Building Features

Appliances Oven, Range, Stainless Steel Appliance(s), Dishwasher
Architecture Historic
Construction Brick
Cooling Wall/Window Unit(s)
Heating Varies by Unit, Electric, Natural Gas
Interior Decor Beamed Ceilings, Natural Woodwork, Built-in Features
Parking Description Gravel, Concrete, Off Street, Driveway
Sewer Public Sewer
Tax Year 2025
Taxes Paid $4,078
Water Public
Fireplaces 3

Community and Schools

Elementary School Perryville Elem.
Junior High School Perry Co. Middle
Senior High School Perryville Sr. High

Price History of 221 W Saint Joseph Street, Perryville, MO

Date Name Price Difference
12/16/2025 Listing Price $560,000 N/A
*Information provided by REWS for your reference only. The accuracy of this information cannot be verified and is not guaranteed.

Map of 221 W Saint Joseph Street, Perryville, MO

Location Map Street View
Photo of Cape Girardeau
Direct: 573-283-3334
Office
230 North Sprigg St.
Cape Girardeau, MO 63701
573-283-3334
Listed by EDGE Realty ERA Powered, Jacob Fish & Kristal Flentge
$
20%
0.72821428571429%
6.75%
$
$
$
Monthly Payment
Principal & Interest
Monthly Taxes
Monthly HOA
Monthly Home Ins.
Monthly PMI
Browse By Area

221 W Saint Joseph Street (MLS #25081439) is a 2 story single family home located in Perryville, MO. This single family home is 3,143 sqft and on a lot of 16,117 sqft (or 0.37 acres) with 6 bedrooms and 5 baths. This property was listed on 12/16/2025 and has been priced for sale at $560,000.

Nearby zip codes are 63764. This property neighbors other cities such as Marble Hill.

Maris

Listing Last updated . Some properties which appear for sale on this web site may subsequently have sold or may no longer be available. Walk Score map and data provided by Walk Score. Google map provided by Google. Bing map provided by Microsoft Corporation.

All information provided is deemed reliable but is not guaranteed and should be independently verified.

Listing information courtesy of: EDGE Realty ERA Powered

Listings displaying the MARIS logo are courtesy of the participants of Mid America Regional Information Systems Internet Data Exchange

Maris

Listing data and photos provided MARIS and distributed by MLS GRID. Member Participants (and their affiliated licensees, if applicable) shall indicate on their websites that IDX information is provided exclusively for consumers’ personal non-commercial use, that it may not be used for any purpose other than to identify prospective properties consumers may be interested in purchasing, that the data is deemed reliable but is not guaranteed by MLS GRID, and that the use of the MLS GRID Data may be subject to an end user license agreement prescribed by the Member Participant’s applicable MLS if any and as amended from time to time. MLS GRID may, at its discretion, require use of other disclaimers as necessary to protect Member Participant, and/or their MLS from liability. Based on information submitted to the MLS GRID. All data is obtained from various sources and may not have been verified by broker or MLS GRID. Supplied Open House Information is subject to change without notice. All information should be independently reviewed and verified for accuracy. Properties may or may not be listed by the office/agent presenting the information.